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It was the best of times it was the worst of times. It was the age of wisdom, it was the age of foolishness. It was the spring of hope, it was the winter of despair.

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popup.style.width = "100%";
popup.innerText =
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This sentence has inline code, useful for making references to variables, packages, versions, etc. within a sentence.

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Consectetur adipiscing elit.

Sed do eiusmod tempor incididunt.

Jekyll Spaceship

$ a * b = c ^ b $

$ 2^{\frac{n-1}{3}} $

$ \int_a^b f(x)\,dx. $

Components

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software

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2023

Example post 3

john-doe February 23, 2023 February 13, 2026

biology medicine

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2021

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Code

const test = "Lorem ipsum dolor sit amet, consectetur adipiscing elit.";

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Nulla facilisi etiam dignissim diam quis. Id aliquet lectus proin nibh nisl condimentum id venenatis a. Tristique magna sit amet purus gravida quis blandit turpis cursus. Ultrices eros in cursus turpis massa tincidunt dui ut ornare. A cras semper auctor neque vitae tempus quam pellentesque nec. At tellus at urna condimentum mattis pellentesque. Ipsum consequat nisl vel pretium. Ultrices mi tempus imperdiet nulla malesuada pellentesque elit eget gravida. Integer vitae justo eget magna fermentum iaculis eu non diam. Mus mauris vitae ultricies leo integer malesuada nunc vel. Leo integer malesuada nunc vel risus. Ornare arcu odio ut sem nulla pharetra. Purus semper eget duis at tellus at urna condimentum. Enim neque volutpat ac tincidunt vitae semper quis lectus.

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Grid of citations

2024

The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction

David Y. Chiang, Arie O. Verkerk, Rachelle Victorio, Boris I. Shneyer, Babet van der Vaart, …, Tuomas Kiviniemi, Paul W. Burridge, Connie R. Bezzina, Anna Akhmanova, Calum A. MacRae

Circulation Research  ·  05 Jan 2024  ·  doi:10.1161/CIRCRESAHA.123.323231

2023

Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification

Peinan Hu, Bingqi Wang, Dongxu Jin, Yedan Gu, Hongyang He, …, Wandi Zhu, David Y. Chiang, Weiming Li, Calum A. MacRae, Yao Zu

Cellular and Molecular Life Sciences  ·  06 Oct 2023  ·  doi:10.1007/s00018-023-04933-2

Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram

Svetlana Maurya, Robert W. Mills, Konstantin Kahnert, David Y. Chiang, Giorgia Bertoli, …, Eli Rothenberg, Alfred L. George, Calum A. MacRae, Mario Delmar, Alicia Lundby

Nature Cardiovascular Research  ·  13 Jul 2023  ·  doi:10.1038/s44161-023-00294-y

Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram

Svetlana Maurya, Robert W Mills, Konstantin Kahnert, David Y Chiang, Giorgia Bertoli, …, Eli Rothenberg, Alfred L George, Calum A MacRae, Mario Delmar, Alicia Lundby

Nature cardiovascular research  ·  01 Jan 2023  ·  PMCID:PMC11041666

Atrial Standstill in the Pediatric Population

Taylor S. Howard, David Y. Chiang, Scott R. Ceresnak, Virginie Beausejour Ladouceur, Robert D. Whitehill, …, Doug Y. Mah, Jeffrey J. Kim, Santiago O. Valdes, Dianna M. Milewicz, Christina Y. Miyake

JACC: Clinical Electrophysiology  ·  01 Jan 2023  ·  doi:10.1016/j.jacep.2022.08.022

2022

Atrial Standstill in the Pediatric Population: A Multi-Institution Collaboration.

Taylor S Howard, David Y Chiang, Scott R Ceresnak, Virginie Beausejour Ladouceur, Robert D Whitehill, …, Doug Y Mah, Jeffrey J Kim, Santiago O Valdes, Dianna M Milewicz, Christina Y Miyake

JACC. Clinical electrophysiology  ·  26 Oct 2022  ·  PMID:36435694

Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, …, Vincent Probst, Arthur A. Wilde, Jean-Jacques Schott, Richard Redon, Connie R. Bezzina

Nature Genetics  ·  26 Apr 2022  ·  doi:10.1038/s41588-022-01079-y

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Julien Barc, Rafik Tadros, Charlotte Glinge, David Y Chiang, Mariam Jouni, …, Vincent Probst, Arthur A Wilde, Jean-Jacques Schott, Richard Redon, Connie R Bezzina

Nature genetics  ·  01 Mar 2022  ·  PMCID:PMC9376964

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.

Julien Barc, Rafik Tadros, Charlotte Glinge, David Y Chiang, Mariam Jouni, …, Vincent Probst, Arthur A Wilde, Jean-Jacques Schott, Richard Redon, Connie R Bezzina

Nature genetics  ·  24 Feb 2022  ·  PMID:35210625

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, …, Vincent Probst, Arthur A. Wilde, Jean-Jacques Schott, Richard Redon, Connie R. Bezzina

Nature Genetics  ·  24 Feb 2022  ·  doi:10.1038/s41588-021-01007-6

2021

Targeting the Microtubule EB1-CLASP2 Complex Modulates Na_V1.5 at Intercalated Discs

Gerard A Marchal, Mariam Jouni, David Y Chiang, Marta Pérez-Hernández, Svitlana Podliesna, …, Paul W Burridge, Mario Delmar, Niels Galjart, Vincent Portero, Carol Ann Remme

Circulation research  ·  23 Jul 2021  ·  PMCID:PMC8298292

Targeting the Microtubule EB1-CLASP2 Complex Modulates Na _V 1.5 at Intercalated Discs

Gerard A. Marchal, Mariam Jouni, David Y. Chiang, Marta Pérez-Hernández, Svitlana Podliesna, …, Paul W. Burridge, Mario Delmar, Niels Galjart, Vincent Portero, Carol Ann Remme

Circulation Research  ·  23 Jul 2021  ·  doi:10.1161/CIRCRESAHA.120.318643

Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart

David Y. Chiang, Satadru Lahiri, Guoliang Wang, Jason Karch, Meng C. Wang, Sung Y. Jung, Albert J. R. Heck, Arjen Scholten, Xander H. T. Wehrens

Proteomes  ·  07 Jun 2021  ·  doi:10.3390/proteomes9020027

2020

The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2

Nilüfer N. Turan, Karni S. Moshal, Karim Roder, Brett C. Baggett, Anatoli Y. Kabakov, …, Yichun Lu, Samuel C. Dudley, Calum A. MacRae, Alain Karma, Gideon Koren

Journal of Biological Chemistry  ·  01 Dec 2020  ·  doi:10.1074/jbc.RA120.015216

The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2

Nilüfer N. Turan, Karni S. Moshal, Karim Roder, Brett C. Baggett, Anatoli Y. Kabakov, …, Yichun Lu, Samuel C. Dudley, Calum A. MacRae, Alain Karma, Gideon Koren

Journal of Biological Chemistry  ·  01 Dec 2020  ·  doi:10.1074/jbc.ra120.015216

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases

Kenshi Hayashi, Ryota Teramoto, Akihiro Nomura, Yoshihiro Asano, Manu Beerens, …, Calum A MacRae, Seiji Takashima, Masakazu Yamagishi, Masa-Aki Kawashiri, Masayuki Takamura

Cardiovascular research  ·  01 Nov 2020  ·  PMCID:PMC8453299

Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation

Hannah M. Campbell, Ann P. Quick, Issam Abu-Taha, David Y. Chiang, Carlos F. Kramm, …, Markus Kamler, Albert J.R. Heck, Stephan E. Lehnart, Dobromir Dobrev, Xander H.T. Wehrens

Circulation  ·  22 Sep 2020  ·  doi:10.1161/circulationaha.120.045791

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases

Kenshi Hayashi, Ryota Teramoto, Akihiro Nomura, Yoshihiro Asano, Manu Beerens, …, Calum A MacRae, Seiji Takashima, Masakazu Yamagishi, Masa-aki Kawashiri, Masayuki Takamura

Cardiovascular Research  ·  24 Jan 2020  ·  doi:10.1093/cvr/cvaa010

2019

LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase

Karni S. Moshal, Karim Roder, Anatoli Y. Kabakov, Andreas A. Werdich, David Yi-Eng Chiang, …, Dmitry Terentyev, Bum-Rak Choi, Alain Karma, Calum A. MacRae, Gideon Koren

Circulation: Genomic and Precision Medicine  ·  01 Sep 2019  ·  doi:10.1161/circgen.119.002641

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation

Katherina M. Alsina, Mohit Hulsurkar, Sören Brandenburg, Daniel Kownatzki-Danger, Christof Lenz, …, Albert J.R. Heck, Na Li, Dobromir Dobrev, Stephan E. Lehnart, Xander H.T. Wehrens

Circulation  ·  20 Aug 2019  ·  doi:10.1161/CIRCULATIONAHA.119.039642

2018

Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression

David Y. Chiang, Katherina M. Alsina, Eleonora Corradini, Martin Fitzpatrick, Li Ni, …, Julia O. Reynolds, Xiaolu Pan, Larry Scott, Albert J.R. Heck, Xander H.T. Wehrens

Circulation  ·  09 Oct 2018  ·  doi:10.1161/CIRCULATIONAHA.118.034361

Wounds That Would Not Heal: Pyoderma Gangrenosum

Joanie Pinard, David Y. Chiang, Arash Mostaghimi, Scott R. Granter, Joseph F. Merola, Ebrahim Barkoudah

The American Journal of Medicine  ·  01 Apr 2018  ·  doi:10.1016/j.amjmed.2017.12.009

Oxidized CaMKII (Ca ²⁺ /Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy

Qiongling Wang, Ann P. Quick, Shuyi Cao, Julia Reynolds, David Y. Chiang, …, Na Li, Guoliang Wang, George G. Rodney, Mark E. Anderson, Xander H.T. Wehrens

Circulation: Arrhythmia and Electrophysiology  ·  01 Apr 2018  ·  doi:10.1161/CIRCEP.117.005682

2017

SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity

Ann P. Quick, Qiongling Wang, Leonne E. Philippen, Giselle Barreto-Torres, David Y. Chiang, …, Hannah M. Campbell, Jordan Showell, Mark D. McCauley, Arjen Scholten, Xander H.T. Wehrens

Circulation Research  ·  06 Jan 2017  ·  doi:10.1161/CIRCRESAHA.116.309977

2016

Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome

David Y. Chiang, Albert J.R. Heck, Dobromir Dobrev, Xander H.T. Wehrens

Journal of Molecular and Cellular Cardiology  ·  01 Dec 2016  ·  doi:10.1016/j.yjmcc.2016.09.009

Relation of Cardiac Dysfunction to Rhythm Abnormalities in Patients With Duchenne or Becker Muscular Dystrophies

David Y. Chiang, Hugh D. Allen, Jeffrey J. Kim, Santiago O. Valdes, Yunfei Wang, Ricardo H. Pignatelli, Timothy E. Lotze, Christina Y. Miyake

The American Journal of Cardiology  ·  01 Apr 2016  ·  doi:10.1016/j.amjcard.2016.01.031

2015

Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture

David Y. Chiang, Jeffrey J. Kim, Santiago O. Valdes, Caridad de la Uz, Yuxin Fan, Jeffrey Orcutt, Melissa Domino, Melissa Smith, Xander H.T. Wehrens, Christina Y. Miyake

Circulation: Arrhythmia and Electrophysiology  ·  01 Oct 2015  ·  doi:10.1161/CIRCEP.115.003098

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation

Edward Glasscock, Niels Voigt, Mark D. McCauley, Qiang Sun, Na Li, …, Constanze Schmidt, Darlene G. Skapura, Jeffrey L. Noebels, Dobromir Dobrev, Xander H. T. Wehrens

Basic Research in Cardiology  ·  11 Jul 2015  ·  doi:10.1007/s00395-015-0505-6

Identification of microRNA–mRNA dysregulations in paroxysmal atrial fibrillation

David Y. Chiang, Min Zhang, Niels Voigt, Katherina M. Alsina, Heinz Jakob, James F. Martin, Dobromir Dobrev, Xander H.T. Wehrens, Na Li

International Journal of Cardiology  ·  01 Apr 2015  ·  doi:10.1016/j.ijcard.2015.01.075

Genetic Deletion of Rnd3/RhoE Results in Mouse Heart Calcium Leakage Through Upregulation of Protein Kinase A Signaling

Xiangsheng Yang, Tiannan Wang, Xi Lin, Xiaojing Yue, Qiongling Wang, …, Xun Ai, David Y. Chiang, Christina Y. Miyake, Xander H.T. Wehrens, Jiang Chang

Circulation Research  ·  02 Jan 2015  ·  doi:10.1161/CIRCRESAHA.116.304940

Alterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients

David Y. Chiang, Nicolas Lebesgue, David L. Beavers, Katherina M. Alsina, J. Mirjam A. Damen, Niels Voigt, Dobromir Dobrev, Xander H.T. Wehrens, Arjen Scholten

Journal of the American College of Cardiology  ·  01 Jan 2015  ·  doi:10.1016/j.jacc.2014.10.042

2014

Loss of MicroRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release

David Y. Chiang, Natee Kongchan, David L. Beavers, Katherina M. Alsina, Niels Voigt, …, Heinz Jakob, James F. Martin, Dobromir Dobrev, Xander H.T. Wehrens, Na Li

Circulation: Arrhythmia and Electrophysiology  ·  01 Dec 2014  ·  doi:10.1161/CIRCEP.114.001973

Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases

David L. Beavers, Andrew P. Landstrom, David Y. Chiang, Xander H.T. Wehrens

Cardiovascular Research  ·  15 Jun 2014  ·  doi:10.1093/cvr/cvu151

Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation

David Y. Chiang, Na Li, Qiongling Wang, Katherina M. Alsina, Ann P. Quick, …, Guoliang Wang, Darlene Skapura, Niels Voigt, Dobromir Dobrev, Xander H.T. Wehrens

Cardiovascular Research  ·  08 May 2014  ·  doi:10.1093/cvr/cvu123

Ryanodine Receptor–Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model

Na Li, David Y. Chiang, Sufen Wang, Qiongling Wang, Liang Sun, …, Frank U. Müller, Miguel Valderrabano, Stanley Nattel, Dobromir Dobrev, Xander H.T. Wehrens

Circulation  ·  25 Mar 2014  ·  doi:10.1161/CIRCULATIONAHA.113.006611

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation

Niels Voigt, Jordi Heijman, Qiongling Wang, David Y. Chiang, Na Li, Matthias Karck, Xander H.T. Wehrens, Stanley Nattel, Dobromir Dobrev

Circulation  ·  14 Jan 2014  ·  doi:10.1161/CIRCULATIONAHA.113.006641

2013

A Coregulatory Network of NR2F1 and microRNA-140

David Y. Chiang, David W. Cuthbertson, Fernanda R. Ruiz, Na Li, Fred A. Pereira

PLoS ONE  ·  03 Dec 2013  ·  doi:10.1371/journal.pone.0083358

Chronic Exercise

Xander H.T. Wehrens, David Y. Chiang, Na Li

Journal of the American College of Cardiology  ·  01 Jul 2013  ·  doi:10.1016/j.jacc.2013.02.070

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development

Julia O. Reynolds, David Y. Chiang, Wei Wang, David L. Beavers, Sayali S. Dixit, Darlene G. Skapura, Andrew P. Landstrom, Long-Sheng Song, Michael J. Ackerman, Xander H.T. Wehrens

Cardiovascular Research  ·  27 May 2013  ·  doi:10.1093/cvr/cvt133

Effects of CaMKII-Mediated Phosphorylation of Ryanodine Receptor Type 2 on Islet Calcium Handling, Insulin Secretion, and Glucose Tolerance

Sayali S. Dixit, Tiannan Wang, Eiffel John Q. Manzano, Shin Yoo, Jeongkyung Lee, David Y. Chiang, Nicole Ryan, Jonathan L. Respress, Vijay K. Yechoor, Xander H. T. Wehrens

PLoS ONE  ·  13 Mar 2013  ·  doi:10.1371/journal.pone.0058655

2012

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome

Sean DeGrande, Derek Nixon, Olha Koval, Jerald W. Curran, Patrick Wright, …, Na Li, Xander H.T. Wehrens, Mark E. Anderson, Thomas J. Hund, Peter J. Mohler

Heart Rhythm  ·  01 Dec 2012  ·  doi:10.1016/j.hrthm.2012.08.026

[no title info]

[no publisher info]  ·  [no date info]  ·  https://doi.org/10.1016/j.hrthm.2025.03.029

Grid of blog posts

2023

Example post 3

john-doe February 23, 2023 February 13, 2026

biology medicine

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

2021

Example post 2

jane-smith September 30, 2021 February 13, 2026

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2019

Example post 1

sarah-johnson January 07, 2019 February 13, 2026

biology medicine big-data

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const test = "Lorem ipsum dolor sit amet";

const test = "Lorem ipsum dolor sit amet";

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